Mangosteen, Xanthones, XanthoMyst

Mangosteen – Why all the sudden interest?

Known for Thousands of Years, Now Only Through Modern Nanoemulsion Technology Can the Full Potential Be Discovered!

Author’s note: This is a scholarly fact-based article, but I decided to write it in the first person so that I could express my personal opinion and tell some stories you might enjoy. You won’t see this as a white paper anytime soon, but I believe you will find value!

Mangosteen is a plant native to SE Asia and has been known for thousands of years, first used as a medicine starting in ancient times. Written records exist in 15th-century Chinese and more recently in Species Plantarum by Linnaeus in 1753.

After centuries of use by naturopathic practitioners, conventional scientific research began around 1980. As the body of knowledge grew, results from animal research caused a sharp expansion in 2005 in tests and reports, and by 2013 significant numbers of human studies exploded to over 4,000 published reports, white papers, and clinical trials by 2017. Why?

Stories have long circulated about the high-performance healing qualities of the fruit from the mangosteen tree, across a wide range of diseases, including:

Inflammation is a common denominator. Mangosteen has been identified as a very effective anti-inflammatory, which is likely why it has been used successfully against such a wide range of diseases. 

Such a wide range of diseases and afflictions raises the question, “Is there a common thread?” At least one common thread is inflammation, which in some cases is the cause, in other cases the result, and in all cases the potential to become a life-threatening raging fire.

In the case of mangosteen, xanthones were discovered to be the active ingredient. Xanthones are found in the pericarp (rind) and have been extracted and combined in nanoemulsions for better concentration.


Xanthones may be defined as an active ingredient high in phytonutrients and known to significantly reduce inflammation, boost immunity, and provide overall health and weight loss benefits. They are found in the pericarp (rind) of mangosteen, a fruit of the Gardenia mangostana, a tropical tree native to Southeast Asia. 

Over 200 xanthones have been discovered as existing in nature and 40+ xanthones, are said to be located in the Xanthone-rich pericarp of the mangosteen fruit. In addition to phytonutrients like xanthones, mangosteen also contains other groups of compounds, including anthocyanins, catechins, and flavonoids, all of which have their own list of studied therapeutic benefits.


It is the anti-inflammatory capabilities of Mangosteen that is of interest in this report. Typically, only 5% of organics are absorbed by the body with 95% going to waste.

The Problem of Density

Some nutrients have been proven highly effective via mega dosing, for example, vitamin C is a powerful antioxidant. A shortage of vitamin C can lead to such conditions as:

  • delayed healing
  • heart disease
  • plaque buildup in the arteries
  • high cholesterol
  • extreme fatigue
  • easy bruising
  • increased susceptibility to infections
  • pain in the muscles and joints
  • poor oral health
  • rough, dry skin

A medium orange has about 67 mg of Vitamin C, barely enough to avoid scurvy. To benefit from a daily dose of 500 mg/C, you would need to eat at least 7 oranges. A megadose of 1500 mg would require eating 22 oranges per day.  Good luck lasting beyond day one! 

Obviously concentrating C into a capsule or pill is highly desirable, although not as enjoyable as eating a nice juicy orange. In the case of mangosteen, the first requirement was to discover the active ingredient, where its concentrated in the fruit, how it works, where it needs to be absorbed in the body, and how much is needed. 

A New Product, A New Approach

CTFO, a company with proprietary product lines in Health, Nutrition, Anti-aging, and Pet-Health, has introduced a product that combines mangosteen pericarp extract with nanoemulsion technology to produce a first-of-its-kind delivery system that delivers the mangosteen pericarp extract in a potent mist, so fine it can’t be swallowed but is immediately absorbed into the tissue within the mouth. Ergo this level of bioavailability was not previously possible.

“Immediately absorbed through the mouth tissue into the bloodstream with maximum bioavailability.”

Does Size Matter?

According to the developing team, the answer is YES!

Keep in mind, generally, the smallest size the human eye can see is about the size of dust at about 25 microns or larger. XanthoMyst nanoemulsion is as tiny as 0.45 microns or less and the liposomes that release the mangosteen xanthones and nutrients are up to ten times smaller.

“We see evidence of the 0.45-micron size because the entire emulsion passes through a 0.45-micron mesh filter without separating or coming apart while remaining stable.”

Size in bioavailability also matters outside the lab for another reason……absorption. Only really small particles get across the gut to the bloodstream. Only small micronized or nanosized particles make it into cells to be used by the body. But if those infinitesimally small particles go into the mouth, the vast majority pass through the mucous membranes of the mouth and are in the bloodstream in seconds!

At this time, this product, XanthoMyst, has not been approved by FDA, and can not be sold as a health solution. It can, however, be acquired as a “food” in the form of a mist that is sprayed into the mouth. If you don’t want to wait and would like to try it now, you can learn more here as well as how to get it!:


CTFO, a company founded in 2015 and heavily invested in the CBD business, previously developed 10X Pure, a process utilizing nanoemulsion technology in their CBD business, which dramatically increased the potency of their CBD product. Now, as of Feb 6, 2023, they are bringing to market their new product, XanthoMyst, which will deliver Xanthone, extracted from Mangosteen Pericarp, using a nanoemulsion process, which will result in a product for inflammation that will be delivered at the cellular level.