If you have Diabetes II, before you make a decision, you should research the information provided in this report, and discuss it with your doctor. I have carefully researched this information and believe it to be accurate, however, I am not a doctor and have presented this for informational purposes only and not as medical advice to anyone. –Glenn Mitch Sitter
A Possible Solution for Chronic Inflammation Caused by Diabetes
The impact of combining xanthones derived from mangosteen pericarp extract with nanoemulsion technology for use in the management of inflammation.
Let’s start with a simplified description of diabetes, the resulting effects of inflammation, and the likely results if untreated.
Diabetes is a state in which the pancreas becomes unable to produce enough insulin to manage blood sugar levels. When cells don’t interact in a normal way with insulin, they don’t take in enough sugar and the pancreas must continuously produce greater and greater amounts of insulin until the cellular need for insulin surpasses the pancreas’ ability to produce it.
Meanwhile, the insulin produced in the pancreas at maximum levels creates irritation of the pancreatic cells and inflammation begins. This inflammation unchecked, can eventually scar the pancreas and render it unable to function. As the inflammation spreads, other organs are affected.
In the kidneys, diabetes-related inflammation can lead to further damage to the already compromised kidneys, leading to kidney failure.
Diabetes-related inflammation in the eyes can cause redness, swelling, and pain, and if left untreated can cause vision loss or even blindness.
Diabetes-related inflammation of the heart is associated with an increased risk of cardiovascular disease, stroke, and other health issues. When the heart is inflamed, it can become stiff and thick, which can lead to heart failure. This is why people with diabetes are at a higher risk of developing cardiovascular diseases. Inflammation also disrupts the normal functioning of the heart, leading to other complications such as arrhythmias and inflammation of the pericardial sack. Furthermore, chronic inflammation can lead to the formation of plaque and blockages in the arteries, which can cause a heart attack.
Diabetes-related inflammation in the nerves can cause loss of sensation and if not managed quickly, can lead to permanent damage to the nervous system, eventually resulting in paralysis. Whether induced by diabetes, chronic stress, obesity, or autoimmune disorders, a chronic state of inflammation can lead to numerous health problems, including heart disease, arthritis, depression, Alzheimer’s disease, and even cancer.
Without proper treatment, inflammation in these organs can have long-term and eventually life-threatening consequences.
Dealing With Inflammation
“Inflammation is present in virtually every disease and unchecked is life-ending.”
OTC and Prescription Drugs
The historic response to inflammation by modern medicine has been the use of NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) in both over-the-counter and prescription-strength drugs. OTC (Over-The-Counter) NSAIDs include pills like aspirin, ibuprofen, and naproxen sodium, while celecoxib (Celebrex) is an example of a prescription drug.
These drugs block inflammatory proteins in the body, called COX-1 and COX-2, to cut inflammation and ease pain. That reduces swelling and fevers, too. Aspirin, unlike other NSAIDs, also prevents your blood from forming clots, which can protect you from heart attacks and strokes. The others may actually promote clots.
These inflammation/painkillers are for short-term use. You shouldn’t take them for more than 10 days for pain and 3 days for fever. If you take them for too long, you are at higher risk for side effects. If you feel you need to take NSAIDs regularly for arthritis pain, talk to your doctor to be sure it’s safe for you. In some people, NSAIDs can cause stomach pain, nausea, bleeding, ulcers, gas, bloating, diarrhea, or constipation. NSAIDs other than aspirin can also raise your risk of heart attack or stroke, even after just 1 week.
Stomach problems are the most common complaint people have about these drugs. To avoid nausea or a belly ache, take your NSAID with food, milk, or antacids. Your doctor can also prescribe acid-controlling medicine to take with NSAIDs to protect your stomach and prevent ulcers.
Some people who can’t tolerate the stomach-related problems that NSAIDs may cause can use prescription celecoxib instead. NSAIDs block two types of COX enzymes, including one that also protects your stomach. Celecoxib only blocks the COX enzyme that causes inflammation and pain. However, high doses of celecoxib could still cause side effects like bleeding.
NSAIDs Addiction, Side Effects
Side effects and complications of NSAIDs are common and serious. In one study, the risk of NSAIDs adverse drug reactions was found to be 26% (Gor 2011). Complications include upper gastrointestinal bleeding and ulcers, heartburn, ringing in the ears, headaches, dizziness, liver or kidney problems, leg swelling, high blood pressure, heart attack, heart failure, stroke, and death.
In June of 1999, The New England Journal of Medicine estimated that 16,500 NSAID-related deaths occur among Americans with rheumatoid arthritis and osteoarthritis every year (Wolfe 1999).
Over 100,000 NSAIDs users are hospitalized per year for gastrointestinal complications. A review of 17 studies found that 11% of preventable drug-related hospital admissions could be attributed to NSAIDs (Howard 2007). In 2005, U.S. Food and Drug Administration issued a public health advisory warning people of the increased cardiovascular risks of NSAIDS, and again in 2007 they published a medication guide for NSAIDs recommending the lowest dose possible for patients using these drugs.
Bioavailability – The Argument Against Herbal Drug Alternatives and the Supplement Industry
95% of your herbal supplement never reaches your bloodstream meaning you have to consume questionable, even dangerous quantities to achieve a result.
Bioavailability is the greatest problem facing the supplement industry today. The most bioavailable supplements are only 5% efficient, meaning that approximately 95% of what you put into your mouth never makes it across the gut and into the bloodstream. Even less makes it into cells to be used in metabolism which is the total of all biological chemical processes necessary to sustain life.
“Let’s face it, if inflammation were an animal, it would be an apex predator!”
Nanotechnology is the doorway to the resolution of Inflammation
Nanotechnology has solved this problem virtually completely; however, to appreciate how this is done we need to look a little bit deeper into how chemical reactions occur.
All chemical reactions take place between two or more particles. All chemical reactions occur only at the surface of interacting particles. Therefore, the surface area of particles available for reaction is the single most important factor in chemical reactivity. Finally, the surface area is inversely related to the size of the reacting particles. Expressed differently, the smaller the particle size, the greater the surface area available for reactions to take place.
As an example, if a large apple has 6 square inches of surface area, chewing it into pieces will increase its size to approximately the surface area of a pickleball court. Then, if the churning of the stomach breaks the apple into applesauce size particles, the surface area may increase to the size of a basketball court. Finally, if we reduce the size of the particles of the apple to the nanoscale, we have a surface area as great as the whole town in which the football field or pickleball court is located!
According to the developing team, the answer is YES!
Keep in mind, generally, the smallest size the human eye can see is about the size of dust at about 25 microns or larger. XanthoMyst nanoemulsion is as tiny as 0.45 microns or less and the liposomes that release the mangosteen xanthones and nutrients are up to ten times smaller.
“We see evidence of the 0.45-micron size because the entire emulsion passes through a 0.45-micron mesh filter without separating or coming apart while remaining stable.”
Size in bioavailability also matters outside the lab for another reason……absorption. Only really small particles get across the gut to the bloodstream. Only small micronized or nanosized particles make it into cells to be used by the body. But if those infinitesimally small particles go into the mouth, the vast majority pass through the mucous membranes of the mouth and are in the bloodstream in seconds!
CTFO, a company founded in 2015 and heavily invested in the CBD business, previously developed 10X Pure, a process utilizing nanoemulsion technology in their CBD business, which dramatically increased the potency of their CBD product. Now, as of Feb 6, 2023, they are bringing to market their new product, XanthoMyst, which will deliver Xanthone, extracted from Mangosteen Pericarp, using a nanoemulsion process, which will result in a product for inflammation that will be delivered at the cellular level.
If Nano-emulsion technology solves the problem of delivery to the bloodstream, then what medicament should be isolated and processed as a Nano-emulsion for delivery into the bloodstream for the treatment of inflammation?
The Promise of Mangosteen
α-Mangostin, a xanthone derivative compound isolated from Garcinia mangostana L. peel extract, has myriad pharmacological effects: antibacterial, antifungal, anti-inflammatory, antiallergic, antioxidant, and anticancer activities. The anticancer activity indicates that α-mangostin might serve as a potent anticancer agent in lung, stomach, colon, cervical, pancreatic, prostate, mammary gland, chondrosarcoma, renal, skin, tongue mucoepidermoid and breast cancers. Source: Scientific Paper, Wathoni, Rusdin, Motoyama, Joni, Lesmana, and Muchtaridi
Xanthones are an active ingredient high in phytonutrients and known to significantly reduce inflammation, boost immunity, and provide overall health and weight loss benefits. They are found in the pericarp (rind) of mangosteen, a fruit of the Gardenia mangostana, a tropical tree native to Southeast Asia.
Over 200 xanthones exist in nature and 40+ xanthones, are said to be located in the Xanthone-rich pericarp of the mangosteen fruit. In addition to phytonutrients like xanthones, mangosteen also contains other groups of compounds, including anthocyanins, catechins, and flavonoids, all of which have their own list of studied therapeutic benefits.
It is the anti-inflammatory capabilities of Mangosteen that is of interest in this report. Typically, only 5% of organics are absorbed by the body with 95% going to waste.
A New Product, A New Approach
CTFO, a company with proprietary product lines in Health, Nutrition, Anti-aging, and Pet-Health, has introduced a product that combines mangosteen pericarp extract with nanoemulsion technology to produce a first-of-its-kind delivery system that delivers the mangosteen pericarp extract in a mist, so fine it can’t be swallowed but is immediately absorbed into the tissue within the mouth. Ergo this level of bioavailability was not previously possible.
“Immediately absorbed through the mouth tissue into the bloodstream with maximum bioavailability.”
At this time, this product, XanthMyst, has not been approved by FDA, and can not be sold as a health solution. It can, however, be acquired from CTFO as a “food” in the form of a mist that is sprayed into the mouth. If you don’t want to wait and would like to try it now, you can order here: cbd-frontiers.myctfo.com
• Extract insoluble Xanthone compounds into a concentrate
• Integrate the concentrate into extremely stable water-soluble liposomal nanoemulsion
• Deliver liposomal nanoemulsion via oral mist for access by your body
• Small micronized liposomal particles more easily absorbed by your body
It is known that xanthone extracted from mangosteen pericarp has a positive effect on inflammation.
First and only source of XanthoMyst. Available here:
A Note About CTFO: Every single customer who purchases any of the CTFO line of products, health, anti-aging, nutrition, or pet health is automatically given an Associates Agreement. There is no requirement of any kind to work for the company, and their customer service is first-rate, but it does provide those who are interested with an opportunity to earn side hustle income. It was this strategy that created the multimillion-dollar company they are today.
To avoid problems, you can only purchase CTFO products from another Associate. If you decide to purchase through my CBD-Frontiers link, I will receive a small commission and you will receive along with leading-edge products of the highest quality, the benefit of my reports similar to this one from time to time. However, there is no obligation of any kind to work for CTFO.
Glenn Mitch Sitter
Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study //www.ncbi.nlm.nih.gov/pmc/articles/PMC5986466/
Xanthones from Mangosteen Extracts as Natural Chemopreventive Agents: Potential Anticancer Drugs
Keywords: Garcinia mangostana, inflammation, insulin resistance, metabolic syndrome, diabetes, xanthones, mangosteen, phytotherapy, dietary supplements
Role of Inflammation in Diabetes
Keywords: Inflammation, diabetes, obesity, metabolic disorders, adipose tissue, anti-inflammatory treatment
Xanthones from Mangosteen Extracts as Natural Chemopreventive Agents:
Potential Anticancer Drugs
Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans
Xanthone defined – Xanthones or xanthonoids are heterotricyclic phytochemicals isolated from a number of plant and fungal sources. From: Advances in Molecular Toxicology, 2017
Nanoparticle Drug Delivery Systems for α-Mangostin //www.dovepress.com/nanoparticle-drug-delivery-systems-for-alpha-mangostin-peer-reviewed-fulltext-article-NSA
Nanoparticle Drug Delivery Systems for α-Mangostin. Nanotechnol Sci Appl. Wathoni N, Rusdin A, Motoyama K, Joni IM, Lesmana R, Muchtaridi M. 2020;13:23-36
Nanoemulsions containing Garcinia mangostana L. pericarp extract for topical applications
Nanoemulsions containing Garcinia mangostana L. pericarp extract for topical applications: Development, characterization, and in vitro percutaneous penetration assay. Elsa Anisa Krisanti, Dyah Paramawidya Kirana, Kamarza Mulia
Published: December 23, 2021
NIH study shows how insulin stimulates fat cells to take in glucose
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